PriceTargets.com logo

Spruce Biosciences - SPRB Stock Price Target and Predictions

  • Consensus Rating: Hold
  • Consensus Price Target: $178.88
  • Forecasted Upside: 97.78%
  • Number of Analysts: 11
  • Breakdown:
  • 1 Sell Ratings
  • 6 Hold Ratings
  • 3 Buy Ratings
  • 1 Strong Buy Ratings
$90.44 As of 12/4/2025 05:00 PM ET
▲ +0.28 (0.31%)

This chart shows the closing price for SPRB by one month, three months, or twelve months.

Skip Closing Price Chart
1 month | 3 months | 12 months
Get New Spruce Biosciences Analyst Ratings Delivered To Your Inbox
Sign-up to receive the latest news and ratings for SPRB and its competitors with Analyst Ratings Network’s free daily newsletter.

Analyst Price Target for SPRB

Analyst Price Target is $178.88
▲ +97.78% Upside Potential
This price target is based on 11 analysts offering 12 month price targets for Spruce Biosciences in the last 3 months. The average price target is $178.88, with a high forecast of $259.00 and a low forecast of $37.50. The average price target represents a 97.78% upside from the last price of $90.44.

This chart shows the closing price for SPRB for the last year in relation to the current analyst high, average, and low pricetarget.

Read Analyst Price Chart DescriptionSkip Analyst Price Chart




Current Consensus is Hold

The current consensus among 11 contributing investment analysts is to hold stock in Spruce Biosciences. This rating has held steady since October 2025, when it changed from a Reduce consensus rating.

Past Monthly Recommendations

Move your mouse over past months for details

Read Past Recommendations DescriptionSkip Past Price Target Consensus Chart
  • 0 strong buy ratings
  • 2 buy ratings
  • 6 hold ratings
  • 0 sell ratings
Ratings as of
6/13/2024
  • 0 strong buy ratings
  • 2 buy ratings
  • 6 hold ratings
  • 0 sell ratings
Ratings as of
9/11/2024
  • 0 strong buy ratings
  • 2 buy ratings
  • 6 hold ratings
  • 0 sell ratings
Ratings as of
12/10/2024
  • 0 strong buy ratings
  • 0 buy ratings
  • 9 hold ratings
  • 0 sell ratings
Ratings as of
3/10/2025
  • 0 strong buy ratings
  • 0 buy ratings
  • 6 hold ratings
  • 0 sell ratings
Ratings as of
6/8/2025
  • 0 strong buy ratings
  • 0 buy ratings
  • 6 hold ratings
  • 0 sell ratings
Ratings as of
9/6/2025
  • 0 strong buy ratings
  • 3 buy ratings
  • 6 hold ratings
  • 1 sell ratings
Ratings as of
11/5/2025
  • 1 strong buy ratings
  • 3 buy ratings
  • 6 hold ratings
  • 1 sell ratings
Ratings as of
12/5/2025

Latest Recommendations

  • 1 strong buy ratings
  • 3 buy ratings
  • 6 hold ratings
  • 1 sell ratings

Display Ratings By
DateBrokerageActionRatingPrice TargetDetails
12/3/2025Leerink PartnrsUpgradeHold ➝ Strong-Buy
12/3/2025Leerink PartnersUpgradeMarket Perform ➝ Outperform$160.00
12/1/2025Weiss RatingsReiterated RatingSell (E+) ➝ Sell (E+)
11/24/2025Weiss RatingsReiterated RatingSell (E+) ➝ Sell (E+)
11/17/2025Weiss RatingsReiterated RatingSell (E+) ➝ Sell (E+)
11/11/2025Weiss RatingsReiterated RatingSell (E+) ➝ Sell (E+)
11/11/2025JMP SecuritiesSet Target$259.00
11/11/2025CitigroupReiterated RatingMarket Perform ➝ Market Perform
11/11/2025Citizens JmpBoost TargetMarket Outperform ➝ Market Outperform$254.00 ➝ $259.00
11/5/2025Weiss RatingsReiterated RatingSell (E+) ➝ Sell (E+)
10/28/2025JMP SecuritiesSet TargetMarket Perform ➝ Market Outperform$254.00
10/28/2025CitigroupUpgradeOutperform
10/28/2025Citizens JmpUpgradeMarket Perform ➝ Outperform$254.00
10/23/2025Zacks ResearchDowngradeStrong-Buy ➝ Hold
10/21/2025Leerink PartnersSet TargetMarket Perform ➝ Market Perform$10.00 ➝ $160.00
10/16/2025Zacks ResearchUpgradeHold ➝ Strong-Buy
10/14/2025Weiss RatingsReiterated RatingSell (D-) ➝ Sell (D-)
9/27/2025Weiss RatingsReiterated RatingSell (E+) ➝ Sell (E+)
4/16/2025Royal Bank Of CanadaLower TargetSector Perform ➝ Sector Perform$112.50 ➝ $37.50
12/16/2024HC WainwrightReiterated RatingNeutral ➝ Neutral
12/12/2024GuggenheimReiterated RatingNeutral ➝ Neutral
12/11/2024Citizens JmpDowngradeStrong-Buy ➝ Hold
12/11/2024Royal Bank Of CanadaReiterated RatingSector Perform ➝ Sector Perform$150.00 ➝ $112.50
12/11/2024JMP SecuritiesReiterated RatingMkt Outperform ➝ Market Perform$225.00 ➝ $225.00
12/11/2024OppenheimerReiterated RatingOutperform ➝ Market Perform
11/12/2024Royal Bank Of CanadaReiterated RatingSector Perform ➝ Sector Perform$150.00 ➝ $150.00
8/19/2024HC WainwrightReiterated RatingNeutral
8/13/2024Royal Bank Of CanadaReiterated RatingSector Perform ➝ Sector Perform$150.00 ➝ $150.00
6/13/2024OppenheimerLower TargetOutperform ➝ Outperform$300.00 ➝ $225.00
6/5/2024HC WainwrightReiterated RatingNeutral
5/14/2024HC WainwrightReiterated RatingNeutral
3/14/2024JMP SecuritiesLower TargetMarket Outperform ➝ Market Outperform$600.00 ➝ $225.00
3/14/2024Leerink PartnrsDowngradeOutperform ➝ Market Perform
3/14/2024GuggenheimDowngradeBuy ➝ Neutral
3/14/2024Leerink PartnersDowngradeOutperform ➝ Market Perform$675.00 ➝ $150.00
3/14/2024Royal Bank Of CanadaDowngradeOutperform ➝ Sector Perform$675.00 ➝ $150.00
3/14/2024LADENBURG THALM/SH SHDowngradeBuy ➝ Neutral
3/14/2024HC WainwrightReiterated RatingBuy ➝ Neutral
3/5/2024Royal Bank Of CanadaReiterated RatingOutperform ➝ Outperform$675.00
2/26/2024Royal Bank Of CanadaBoost TargetOutperform ➝ Outperform$600.00 ➝ $675.00
2/21/2024GuggenheimInitiated CoverageBuy$750.00
11/20/2023HC WainwrightReiterated RatingBuy ➝ Buy$750.00
9/13/2023HC WainwrightReiterated RatingBuy ➝ Buy$750.00
9/13/2023Royal Bank Of CanadaReiterated RatingOutperform ➝ Outperform$600.00
9/8/2023Leerink PartnersUpgradeMarket Perform ➝ Outperform$225.00 ➝ $675.00
8/18/2023OppenheimerLower TargetOutperform ➝ Outperform$600.00 ➝ $525.00
8/18/2023HC WainwrightReiterated RatingBuy ➝ Buy$750.00
8/16/2023JMP SecuritiesBoost TargetOutperform ➝ Outperform$525.00 ➝ $600.00
8/15/2023Royal Bank Of CanadaReiterated RatingOutperform ➝ Outperform$600.00
6/13/2023HC WainwrightReiterated RatingBuy
3/23/2023HC WainwrightLower TargetBuy$1,500.00 ➝ $750.00
3/17/2023Credit Suisse GroupReiterated RatingOutperform$300.00
2/13/2023Royal Bank Of CanadaLower TargetOutperform$675.00 ➝ $600.00
11/17/2022OppenheimerLower TargetOutperform$975.00 ➝ $600.00
11/16/2022JMP SecuritiesInitiated CoverageMarket Outperform$600.00
6/21/2022HC WainwrightReiterated RatingBuy$1,500.00
3/16/2022Leerink PartnersLower TargetMarket Perform$375.00 ➝ $225.00
3/15/2022Royal Bank Of CanadaLower TargetOutperform$975.00 ➝ $675.00
3/8/2022LADENBURG THALM/SH SHInitiated CoverageBuy$450.00
1/25/2022HC WainwrightReiterated RatingBuy$1,500.00
1/6/2022HC WainwrightReiterated RatingBuy$1,500.00
12/16/2021OppenheimerInitiated CoverageOutperform$1,125.00
12/10/2021BenchmarkInitiated CoverageSpeculative Buy$525.00
11/23/2021CowenDowngradeOutperform ➝ Market Perform
11/16/2021Credit Suisse GroupLower TargetOutperform$1,950.00 ➝ $450.00
11/16/2021HC WainwrightLower TargetBuy$2,250.00 ➝ $1,500.00
11/16/2021Leerink PartnersDowngradeOutperform ➝ Market Perform$2,625.00 ➝ $375.00
8/26/2021HC WainwrightReiterated RatingBuy$2,250.00
7/19/2021HC WainwrightInitiated CoverageBuy$2,250.00
5/18/2021Leerink PartnersReiterated RatingBuy$2,625.00
3/23/2021Credit Suisse GroupLower TargetOutperform$2,100.00 ➝ $1,950.00
(Data available from 12/5/2020 forward)

News Sentiment Rating

0.39 (Hold)

Our news sentiment rating is based on the average sentiment of articles about this company published in the media in the last 30 days of headlines and can range from 2 (very positive sentiment) to -2 (very negative sentiment).

News Sentiment Over Time

Move your mouse over past months for details

Skip to Current Sentiment Summary
  • 1 very positive mentions
  • 6 positive mentions
  • 0 negative mentions
  • 0 very negative mentions
Mentions as of
5/9/2025
  • 0 very positive mentions
  • 0 positive mentions
  • 0 negative mentions
  • 0 very negative mentions
Mentions as of
6/8/2025
  • 1 very positive mentions
  • 3 positive mentions
  • 0 negative mentions
  • 0 very negative mentions
Mentions as of
7/8/2025
  • 0 very positive mentions
  • 3 positive mentions
  • 0 negative mentions
  • 0 very negative mentions
Mentions as of
8/7/2025
  • 0 very positive mentions
  • 2 positive mentions
  • 0 negative mentions
  • 0 very negative mentions
Mentions as of
9/6/2025
  • 0 very positive mentions
  • 1 positive mentions
  • 0 negative mentions
  • 0 very negative mentions
Mentions as of
10/6/2025
  • 6 very positive mentions
  • 34 positive mentions
  • 2 negative mentions
  • 1 very negative mentions
Mentions as of
11/5/2025
  • 3 very positive mentions
  • 11 positive mentions
  • 0 negative mentions
  • 0 very negative mentions
Mentions as of
12/5/2025

Current Sentiment

  • 3 very positive mentions
  • 11 positive mentions
  • 0 negative mentions
  • 0 very negative mentions

Recent Stories by Sentiment

Very Negative

  • No very negative mentions tracked during this time.

Negative

  • No negative mentions tracked during this time.

Positive

Very Positive

Spruce Biosciences logo
Spruce Biosciences, Inc., a biopharmaceutical company, focuses on developing and commercializing novel therapies for rare endocrine disorders. The company engages in developing tildacerfont, a non-steroidal therapy to enhance disease control and reduce steroid burden for patients suffering from congenital adrenal hyperplasia (CAH), which is in Phase 2b clinical trial; and to evaluate glucocorticoid reduction in adult patients with classic CAH that is Phase 2b clinical trial. It is also developing tildacerfont for the treatment of pediatric classic congenital adrenal hyperplasia in children that is in Phase 2 clinical trial; and for females with polycystic ovary syndrome, which is in Phase 2 clinical trial. Spruce Biosciences, Inc. has a license agreement with Eli Lilly and Company to research, develop, and commercialize compounds for various pharmaceutical uses; and collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize tildacerfont for the treatment of CAH in Japan. The company was incorporated in 2014 and is headquartered in South San Francisco, California.
Read More

Today's Range

Now: $90.44
Low: $83.00
High: $92.40

50 Day Range

MA: $109.98
Low: $7.81
High: $182.60

52 Week Range

Now: $90.44
Low: $4.28
High: $240.00

Volume

47,664 shs

Average Volume

184,366 shs

Market Capitalization

$96.77 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

3.45

Frequently Asked Questions

What sell-side analysts currently cover shares of Spruce Biosciences?

The following Wall Street analysts have issued stock ratings on Spruce Biosciences in the last year: Citigroup Inc., Citizens Jmp, Guggenheim, HC Wainwright, JMP Securities, Leerink Partners, Leerink Partnrs, Oppenheimer Holdings, Inc., Royal Bank Of Canada, Wall Street Zen, Weiss Ratings, and Zacks Research.
View the latest analyst ratings for SPRB.

What is the current price target for Spruce Biosciences?

0 Wall Street analysts have set twelve-month price targets for Spruce Biosciences in the last year. Their average twelve-month price target is $178.88, suggesting a possible upside of 97.8%. JMP Securities has the highest price target set, predicting SPRB will reach $259.00 in the next twelve months. Royal Bank Of Canada has the lowest price target set, forecasting a price of $37.50 for Spruce Biosciences in the next year.
View the latest price targets for SPRB.

What is the current consensus analyst rating for Spruce Biosciences?

Spruce Biosciences currently has 1 sell rating, 6 hold ratings, 3 buy ratings and 1 strong buy rating from Wall Street analysts. The stock has a consensus analyst rating of "Hold." A "hold" rating indicates that analysts believe investors should keep any existing positions they have in SPRB, but not buy more shares or sell existing shares.
View the latest ratings for SPRB.

What other companies compete with Spruce Biosciences?

Other companies that are similar to Spruce Biosciences include Ocugen, Tectonic Therapeutic, PepGen, Autolus Therapeutics and Galectin Therapeutics. Learn More about companies similar to Spruce Biosciences.

How do I contact Spruce Biosciences' investor relations team?

The company's listed phone number is 415-655-4168 and its investor relations email address is [email protected]. The official website for Spruce Biosciences is www.sprucebiosciences.com. Learn More about contacing Spruce Biosciences investor relations.